Duphaston and planning pregnancy: taking the drug correctly. Side effects and overdose

Duphaston is a hormonal pill that women take if they have problems with their reproductive system. The drug is a synthetic analogue of progesterone. You should drink it only after your doctor confirms that you have hormone deficiency. Self-medication can negatively affect a woman’s health and only worsen her illness.

Reception features

Sometimes girls take medicine, guided by schemes written on forums, or do not adhere to the rules at all. They may miss taking Duphaston one or more times, which is why they will not achieve any effect at all.

Today, various variations of treatment courses are described in the instructions for the drug. However, if you take the pills exactly according to these schemes, there is no guarantee of success. For each patient, the doctor individually prescribes a cycle of therapy. And he tells the woman what to do after missing a dose of Duphaston.

Approximate patterns of tablet use depend on the diagnosis and are as follows:

  • For treatment of endometriosis take one tablet three times a day, starting from day 5 of the cycle until day 25.
  • Infertility treatment continue from 3 months to six months. Take one capsule twice a day. The dose may vary depending on the degree of hormonal deficiency.
  • Maintenance therapy during pregnancy, it is carried out in the same dosages as before its onset. However, if you miss the Duphaston tablet, the risk of fetal rejection increases.
  • If a woman threatening abortion begins, then you should take 4 tablets at a time. After 8 hours, take another dose, after which they continue to take one tablet per day for a week.
  • When performing a routine abortion(several miscarriages in a row), a woman is prescribed one tablet per day from days 11 to 25 of the menstrual cycle, 3-6 months before pregnancy.
  • To even out menstruation the patient is prescribed 2 capsules per day in the morning and evening in the second phase of the cycle (from 11 to 25 days) for several months.

Skipping a pill while following any of the listed regimens may not have any consequences, but may lead to unexpected reactions. Therefore, Duphaston must be used carefully, strictly adhering to the course.

What to do after missing a dose

There are many things to do and unforeseen situations that can cause you to forget to take Duphaston. Hormonal medications are taken on certain days, and some even at set times. Usually, missing at least one dose does not have a very good effect on a woman’s health, but in the case of Duphaston, everything is not so bad.

If the patient misses a Duphaston tablet, she must drink it within 6 hours. In this case, there will be no consequences.


A delay of more than 6 hours may have a negative impact on reproductive function. However, you no longer need to take the medicine, and the course should be continued according to the regimen prescribed by the doctor.

If you skip Duphaston during pregnancy, the risk of spontaneous abortion increases. Especially if this happened in the first few weeks of the term in girls prone to miscarriages. A woman should set herself reminders to take pills so as not to undermine the health of her baby.

Consequences of missing

Abruptly stopping Duphaston is strictly prohibited. The female body reacts inadequately due to the sudden cessation of hormones. Therefore, if a girl missed taking Duphaston, she may be worried about:
  • sudden uterine bleeding;
  • heavy menstruation, uncharacteristic of the cycle phase;
  • delayed discharge;
  • occurrence of side effects drug.
As a rule, these conditions resolve themselves if you continue to take the medicine without skipping. And in order for taking Duphaston during and before pregnancy to be as safe as possible, you should carefully adhere to the developed regimen.

Quite often a person finds himself in a situation where he needs to take certain medications. Hormonal drugs are in most cases prescribed to representatives of the fairer sex. It is their body that undergoes cyclical changes every month. One of the most popular prescribed drugs is artificial progesterone. It is worth considering in detail how to take Duphaston.

How does the female body work?

Every month a woman begins a new cycle. It consists of two phases: first and second. The cycle is divided into parts by the day when the egg is released from the ovary.

In the first part of the month, the woman’s body releases hormones that are necessary for the proper growth of the egg and the preparation of the uterine layer for pregnancy.

The second phase is called the luteal phase. During it, a strong release of the hormone progesterone is observed. It is he who is responsible for the normal course of pregnancy in the event of fertilization. The drug "Duphaston" is an artificial substitute for progesterone.

When is this medicine prescribed?

The doctor prescribes Duphaston tablets only after a preliminary examination. It can be recommended to a woman in the following cases:


It is worth noting that it is always necessary to comply with the prescribed dosage and treatment time.

How to take Duphaston?

Depending on the diagnosis given to the woman and the cause of the illness, an individual dose of the drug is selected. Also, the dosage and time of taking the drug may vary. Let's look at how to take Duphaston correctly for a particular disease.

During the threat of spontaneous miscarriage

If a pregnant woman is at risk of miscarriage, then in most cases she is prescribed this particular remedy. The doctor decides how to take Duphaston in this case. It all depends on the severity of the symptoms and the cause of their occurrence.

In most cases, the patient is prescribed a single dose of four tablets, which is forty milligrams of the drug. After this, it is recommended to take one capsule every eight hours. This must be done until the symptoms disappear completely: pain, bleeding, feeling unwell.

If a woman is at risk of miscarriage due to a lack of progesterone in the body, then how to take the medicine in this case? Usually the doctor prescribes two tablets per day, which must be taken at equal intervals. It is worth noting that in such a situation, the treatment time with Duphaston increases significantly. A specialist will tell you how long you can take it. In most cases, such treatment is prescribed before the beginning of the second trimester of pregnancy, when the placenta completely takes over the production of the necessary hormone.

Duphaston tablets for infertility: how to take?

Quite often, this drug is prescribed to women planning pregnancy. If a representative of the fair sex has regular sex life without using contraception, but conception does not occur, then she should consult a doctor. The first symptom of phase two deficiency is its short length. After testing for the required hormone, the doctor may recommend taking it additionally.

So, how to take Duphaston to get pregnant? In most cases, the medication is prescribed one tablet per day. You need to drink them from the 14th day after the start of your last period until the 25th day. However, when prescribing this, it is worth remembering that this regimen is only suitable for women with a regular cycle of 28 days. If you have a longer cycle, you can only take additional progesterone after ovulation. Otherwise, you may achieve the opposite contraceptive effect. Taking Duphaston before the egg leaves the ovary can simply suppress it.

For hormonal diseases

Very often, for various pathologies associated with improper production of hormones, progesterone is prescribed. One of the treatment options may be the prescription of Duphaston tablets for endometriosis. How to take the medicine in this case depends on the severity of the symptoms of the disease and the stage of the disease.

As a rule, doctors adhere to following diagram. The patient is prescribed to take one capsule two to three times a day. The duration of treatment is 11 days: from the 14th day from the beginning of the last menstruation to the 25th.

For a more serious stage of the disease, the doctor may prescribe continuous use of the drug. In this case, the woman needs to take one pill twice a day. Reception should be carried out at regular intervals. Only in this case can the maximum effect of treatment be achieved.

For female cycle disorders

If a representative of the fair sex experiences irregular menstruation, she may also be prescribed an additional dose of progesterone. In case of severe premenstrual syndrome, the doctor may recommend the use of Duphaston tablets.

In these cases, the drug is prescribed from the 11th day from the beginning of the last menstruation. The course of taking the drug should continue until the 25th day of the cycle. You need to take the medicine one tablet 2 times a day at equal intervals.

In case of prolonged absence of menstruation (amenorrhea)

How to take Duphaston if a woman does not have periods, but this is not related to pregnancy? In this case, the use of this medicine is prescribed from 11 to 25 days of the cycle. It is imperative to supplement treatment with medications containing estrogens.

For bleeding of unknown origin

To stop bleeding, the drug Duphaston is prescribed for one week. You need to take it twice a day, one capsule. Before prescribing the drug, it is necessary to establish the cause of such discharge.

To prevent dysfunctional bleeding, it is prescribed to take one capsule twice a day during the menstrual cycle - from 11 to 25 days.

With hormonal replacement therapy (after removal of the ovaries)

If a regimen in combination with estrogens is chosen, then one drug is prescribed in the first two weeks. In the next two weeks, you need to take Duphaston tablets.

If taking estrogen is contraindicated, then only artificial progesterone is prescribed for two weeks, after which it is necessary to take a break for 10-15 days.

The dosage of the drug in these cases is 10 mg, that is, one capsule per day.

In case of tumor processes in the female body

If a woman has cysts on the ovaries or other organs, then how to take Duphaston in this case?

If the tumor is estrogen-dependent, which is most often the case, then the medicine is prescribed two tablets per day throughout the entire cycle. The goal of treatment in this case is to suppress the production of estrogen.

Correct selection of drug dosage

This medicine is usually available in the following form: V cardboard box plate with 20 tablets. One pill contains 10 milligrams of the drug. But in some cases, you may find a higher dosage of 20 milligrams. You must always pay attention to this, since in this case it is necessary to take Duphaston tablets according to a different scheme.

Conclusion

If you are prescribed the drug Duphaston, you must adhere to the selected course of treatment. In each individual case, the regimen for using the drug must be individual. Otherwise, you will not get an effective result from the hormonal treatment.

Before prescribing the drug, a preliminary examination should always be carried out. It is also necessary to take into account the duration of the female cycle.

Monitor the state of your hormones and carry out the necessary treatment on time. Be healthy!

Many women face problems conceiving or complications during pregnancy. Scientists have found that one of the factors that provokes such deviations is hormonal imbalance or progesterone deficiency in a woman’s body. To solve these problems, as well as for the treatment and prevention of infertility, normalization of ovulation, doctors prescribe Duphaston during or before pregnancy.

Duphaston - instructions for use during pregnancy

The ovaries and adrenal glands in a woman’s body play one of the main roles - they produce the steroid hormone progesterone, which is necessary for normal menstruation and successful conception. However, for various reasons, malfunctions of these systems may occur, which will lead to a decrease in the level of the hormone in a woman’s blood. In this case, for successful gestation of the fetus, medical advice is prescribed. drug Duphaston.

It is an analogue of the hormone progesterone of natural origin and is well accepted by the woman’s body. The drug does not affect the functioning of the liver, but at the same time normalizes the tone of the smooth muscles of the uterus without disrupting the menstrual cycle and ovulation. This effect on the body increases the chances of successfully bearing a baby: it prevents the risks of miscarriages or embryo freezing. If a woman has been diagnosed increased tone uterus, then when taking these pills in 85% of cases the child can be saved.

Composition and release form

The medicine is sold in cardboard packs of 20 or 14 tablets. In addition to the blisters, the box contains detailed instructions by application. The tablets themselves are small, round with a division in the middle. On back side The packaging contains information about the manufacturer, storage rules and composition are indicated. According to this, 1 tablet contains:

Effect of the drug

When using the medicine, the deficiency of natural hormones is compensated, due to which the percentage of spontaneous miscarriage in the first weeks of pregnancy, the risks of developing fetal defects and deviations in the formation of the placental layer. Additional intake of synthetic progesterone into the body normalizes a woman’s hormonal levels and ensures normal nutritional and oxygen balance for the fetus.

Absorption of active components into the blood occurs in the intestinal mucosa. The maximum concentration of substances is achieved 1.5-2 hours after taking the medication. The half-life of the active components occurs in the liver, and the remaining medication is excreted by the kidneys along with urine. The duration of their complete elimination is 70 hours.

Indications for use

The main indication for prescribing Duphaston is a deficiency of natural progesterone in the body. Before starting treatment, a woman must undergo tests to confirm suspicions. According to instructions, It is advisable to take pills:

  • in the treatment of menstrual cycle disorders - delayed menstruation, normalization of the second stage of the cycle;
  • with severe premenstrual syndrome – abdominal pain, lower back pain, migraines;
  • if there is a threat of termination of an early pregnancy;
  • with endometriosis;
  • for the treatment of infertility;
  • to preserve the fetus;
  • with threatened or habitual abortion.

Duphaston in early pregnancy

During pregnancy, the medicine will compensate for the lack of progesterone and take over its functions. The drug will support the activity of the corpus luteum during conception, relax the endometrium of the uterus, and have an immunosuppressive effect so that the body does not perceive the fertilized egg as a foreign body. If signs appear early in pregnancy spontaneous interruption or another threat of miscarriage, taking a synthetic hormone is useful for maintaining pregnancy.

In the later stages

The duration of taking the tablets is determined by the doctor. As a rule, the medication is prescribed before conception and it is recommended to continue taking it until 16-20 weeks of pregnancy. However, if there are certain indications, the doctor may prescribe Duphaston for later pregnancy. One of the reasons is increased uterine tone when there are risks premature birth. Anyway The drug should be stopped before 36 weeks of pregnancy.

How to take Duphaston correctly

The dosage of Duphaston and the course of treatment are selected individually by the doctor in accordance with test data, the general picture and the patient’s complaints. As a rule, when planning a pregnancy, taking the drug begins several weeks before conception and continues until the 16th week. If the level of hormones has decreased in the later stages of pregnancy, treatment is continued until 24-25 weeks.

According to the instructions, the tablet dosage regimen is as follows:

  • When the endometrium grows, take 1 tablet of Duphaston 2-3 times a day, constantly or with last day menstrual cycle on day 25.
  • If the level of estrogen hormones is high, but the level of the hormone progesterone is low in the luteal phase, take 1 tablet of the medicine from the moment of ovulation to the 25th day of the cycle. The recommended course of treatment is 6 months, and after conception - throughout the entire first trimester of pregnancy.
  • If there is a threat of miscarriage, spontaneous abortion or other pathologies, 4 tablets are prescribed for the first time, then 1 tablet 3 times a day until the problem is eliminated.
  • To prevent or eliminate uterine bleeding, doctors recommend taking 1 tablet 2 times a day for 7 days.

Skipping a drug dose

You need to take the pills regularly, without missing a single day. If, while treating certain problems, you accidentally forgot to take Duphaston, according to the instructions, you need to drink the prescribed dose of the drug within the next 6 hours. If more time has passed since taking the recommended dose, then you should not take an additional tablet, you need to continue treatment according to the prescribed regimen.

How to stop Duphaston during pregnancy

Cancellation of hormonal therapy should be gradual and only on the recommendation of the attending physician, when the level of progesterone, according to laboratory indicators, has returned to normal. Abruptly stopping any hormonal medications can lead to side effects and cause irreversible reactions in the body. Duphaston should be discontinued during pregnancy according to the following scheme:

  • If a woman previously took 2 tablets per day, then the dosage of the drug should be reduced to 1.5 tablets.
  • After a week, the same dosage should be reduced to 1 tablet and so on until the medication is completely stopped.

special instructions

Combined use of the drug with medications containing estrogen hormones should be prescribed with caution to patients with renal failure, heart or vascular disease, epilepsy, diabetes or chronic headaches. The active components of Duphaston do not affect the speed of thinking and reaction. When undergoing hormonal therapy, you should undergo regular mammography examinations.

Interactions with drugs

Throughout treatment, and especially at the beginning of pregnancy, you should not combine Duphaston for pregnant women with broad-spectrum antibiotics, sleeping pills or antiepileptic drugs such as Rifampicin or Phenobarbital. Otherwise, Duphaston may not have the desired effect. There are no known cases of incompatibility of this drug with other medications.

Side effects and overdose

Pregnancy with Duphaston, as a rule, proceeds without consequences for the mother and child. However, in rare cases, side effects may occur that can be easily eliminated by adjusting the dosage. Among the negative reactions there are the following cases:

  • If you take too small a dose, spotting from the uterus may appear.
  • Sometimes there is breast tenderness, discomfort in the epigastric region and headaches.
  • Very rarely, skin rashes, fluid accumulation - swelling of the limbs and other allergic reactions are possible.
  • Some women experience decreased or increased sexual desire when taking hormonal medications.
  • There have been no cases of Duphaston overdose during pregnancy.

Contraindications

Duphaston and pregnancy are two inseparable concepts. However, the drug is prescribed with caution if a pregnant woman has a history of liver dysfunction - jaundice, severe itching. The second most important indicator for drug withdrawal is the tendency to allergic reactions to one or more substances from the composition. Stop taking the drug if the pregnancy is frozen, bleeding of unknown origin occurs, or ectopic pregnancy. It is strictly forbidden to take pills if you have:

  • Rotor or Dubin-Jones disease;
  • severe liver diseases;
  • malignant neoplasms of the mammary glands or genital organs;
  • severe thrombophlebitis or a tendency to thrombosis.

Terms of sale and storage

In pharmacies, Duphaston is dispensed upon presentation of a prescription from a gynecologist. The tablets must be stored at a temperature of 0 to 30 degrees Celsius in a place protected from sunlight and children. Do not take Duphaston after the expiration date indicated on the carton. If all conditions are met, the maximum shelf life is 5 years.

Duphaston's analogues

Synonymous drugs should not only differ from Duphaston in price, but also have similar properties and principles of action on the body of a pregnant woman. Moreover, some medications may have a distinctive composition, which is a plus for those who suffer from individual intolerance to dydrogesterone or other substances. If there is a risk of miscarriage or disturbances in the formation of the placenta, the doctor may prescribe one of the following analogues of Duphaston:

  • Duphaston;
  • Dydrogesterone;
  • Utrozhestan;
  • Progesterone;
  • Lutein;
  • Ingesta.

Duphaston price

You can buy the drug at any pharmacy at an affordable price or order home delivery of the medicine from the online store. Upon receipt of the goods, you are required to provide the seller with an original prescription from a doctor. How much Duphaston costs in Moscow pharmacies is shown in the table:

Duphaston is a synthetic hormonal drug of the latest generation, which is an artificial analogue of the female hormone progesterone.

A unique feature of the drug lies in its chemical formula, which is almost identical to the structure of the natural hormone progesterone. It is necessary female body to ensure biological changes associated with preparation for pregnancy and its normal course. The basis of the drug is the progestogen hormone – dydrogesterone. It acts directly on the lining of the uterus, which eliminates most of the side effects that accompany the use of other synthetic hormones.

On this page you will find all the information about Duphaston: complete instructions for use for this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Duphaston. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The active component of the drug dydrogesterone is an analogue of natural progesterone. Duphaston is a hormonal drug.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Duphaston cost? The average price in pharmacies is 480 rubles.

Release form and composition

Film-coated tablets, 10 mg. 20 tablets in PVC/Al blister. 1 PVC/Al blister along with instructions for use is placed in a cardboard box.

  • 1 film-coated tablet contains: active substance: dydrogesterone, 10 mg;
  • Excipients: lactose monohydrate, hypromellose, corn starch, colloidal silicon dioxide, magnesium stearate;
  • Shell: Opadry white Y-1-7000 (hypromellose, polyethylene glycol 400, titanium dioxide (El 71)).

Round biconvex tablet white, beveled, film-coated, scored on one side, engraved with an “S” over the “T” on one side of the tablet and “155” on the other side (on both sides of the score).

Pharmacological effect

According to its molecular structure, pharmacological and chemical properties Dydrogesterone is close to natural progesterone. This element is not a testosterone derivative and does not have the side effects that are inherent in almost all synthetic progestogens, which are also called androgenic progestogens. Dydrogetestrone has no glucocorticoid, anabolic, androgenic, estrogenic or thermogenic activity.

According to the instructions, Duphaston is part of a comprehensive HRT for menopause; the drug retains a beneficial effect on the blood lipid profile from estrogen. Unlike estrogen hormones, which negatively affect the blood coagulation system, dydrogestron has no effect on the coagulation rate. The drug does not have instructions for planning conception negative influence on liver function, carbohydrate metabolism.

When taken orally, dydrogesterone selectively acts on the endometrium, which helps prevent an increased risk of developing hyperplasia or carcinogenesis due to excess estrogen. The medication according to the instructions is indicated for endogenous progesterone deficiency. Duphaston does not have a contraceptive effect, because it is used when planning pregnancy. The drug makes conception possible and ensures the maintenance of pregnancy during therapy.

Indications for use

The use of Duphaston is indicated in cases where there is or suspected deficiency of endogenous progesterone, in cases where its positive effect has been clinically proven:

  • infertility caused by luteal insufficiency;
  • threatened abortion;
  • habitual abortion;
  • premenstrual syndrome;
  • dysmenorrhea;
  • irregular cycle.

In addition, in combination with estrogens, Duphaston can be used for:

  • secondary amenorrhea;
  • dysfunctional uterine bleeding.

Contraindications

You should not take the medicine:

  1. Lactase deficiency, galactose and glucose intolerance, malabsorption syndrome;
  2. Breastfeeding period;
  3. Hypersensitivity to the components of the drug.

If the patient's history indicates itching during a previous pregnancy, Duphaston should be used with caution.

Use during pregnancy and lactation

According to the instructions, Duphaston is used during pregnancy according to indications.

Since dydrogesterone can be released from breast milk, if treatment with the drug is necessary, it is recommended to stop breastfeeding.

Instructions for use

The instructions for use indicate that Duphaston tablets are taken orally. The dosage of the drug must correspond to the diagnosis. Treatment is carried out only as prescribed by a doctor and under medical supervision.

  1. Infertility caused by luteal insufficiency– prescribe 1 tablet per day from the 14th to the 25th day of the cycle. The drug is taken for at least six months or 6 cycles. If conception has already occurred, then Duphaston should be taken further, as if there is a threat of abortion.
  2. Endometriosis - dosage 10 mg (1 tablet) 2 to 3 times a day. Start either from the 5th to the 25th day of the monthly cycle, or continuous use.
  3. Habitual abortion - take 1 tablet 2 times a day. Treatment should be continued until the 20th week of pregnancy, then the dosage is gradually reduced.
  4. Threatened abortion– take 40 mg (4 tablets) once. Then 1 tablet every 8 hours until the situation returns to normal. If symptoms begin to increase again, the dose of the drug should be increased again. Next, Duphaston should be taken until 12–20 weeks of pregnancy.
  5. Prolonged absence of menstruation (amenorrhea)– complex treatment – ​​estrogen-containing drugs, 1 tablet per day, starting from the 1st day of the cycle. From the 11th day of the cycle, treatment is supplemented with Duphaston. These drugs should be taken until the 25th day of the cycle. Application is intended for at least 3 menstrual cycles.
  6. Painful periods– 1 tablet 2 times a day. Use is indicated from the 5th to the 25th day of the cycle.
  7. PMS - prescribed 1 tablet 2 times a day. Treatment is carried out from the 11th to the 25th day of the cycle. The drug is prescribed for a period of 3 to 6 months.
  8. Irregular monthly cycle– the drug is prescribed in 1 tablet. 2 times a day. Duphaston should be used from the 11th to the 25th day of the cycle.
  9. Hormone replacement therapy– prescribed in combination with estrogens, 1 tablet once a day for 2 weeks within a 28-day cycle. Usually the reception takes place in the last 14 days of the cycle. If the response to progesterone therapy is not detected by ultrasound and is not confirmed by tests, then the dose should be revised upward.
  10. Dysfunctional uterine bleeding– the dose is 1 tablet. 2 times a day. The duration of treatment is from 5 to 7 days. To prevent bleeding, the drug is prescribed - 1 table. 2 times a day. Therapy is carried out from the 11th to the 25th day of the cycle.

Side effects

When taking Duphaston, adverse reactions may develop:

  1. The hematopoietic system may respond to the drug with symptoms of hemolytic anemia.
  2. From the central nervous system, dizziness and headaches are possible.
  3. From the genital area, breakthrough uterine bleeding sometimes occurs, and sometimes there is soreness and swelling of the mammary glands.
  4. On the skin side, allergic manifestations are possible in the form of urticaria, itching, skin rash. In very rare cases, a complication such as Quincke's edema develops.
  5. In some cases, problems with the liver are noted, expressed in weakness and malaise, jaundice; some patients note that their stomach hurts after Duphaston.

Uterine bleeding when taking the drug is easily stopped by increasing the dose of Duphaston. If adverse reactions occur, you should consult your doctor; you may need to adjust the dose, and if allergic reactions develop, discontinue the drug.

Overdose

There have been no reports of overdose symptoms. In case of accidental ingestion at a dose significantly higher than the therapeutic dose, gastric lavage is recommended. There is no specific antidote; treatment should be symptomatic.

special instructions

Currently, there is no data on the negative effects of dydrogesterone in chronic renal failure.

A thorough clinical examination is required if there is a history of a progesterone-dependent tumor (for example, meningioma), as well as if it progresses during pregnancy or during previous hormonal therapy.

When prescribing dydrogesterone in combination with estrogens (for example, for hormone replacement therapy), contraindications and warnings associated with the use of estrogens should be taken into account.

Before starting hormone replacement therapy (HRT), a complete medical history should be obtained. During treatment, it is recommended to periodically monitor individual tolerance to HRT. The patient should be informed about what changes in the mammary glands she should report to the doctor. Studies including mammography should be performed in accordance with routine patient screening.

Sometimes, during the first months of treatment, breakthrough uterine bleeding may occur. If breakthrough bleeding occurs after a certain period of taking the drug or continues after a course of treatment, the cause should be investigated and an endometrial biopsy should be performed to exclude malignant changes in the endometrium.

Duphaston tablets should not be prescribed to patients with genetically determined galactose intolerance, lactase deficiency or malabsorption syndrome.

Drug interactions

There may be a slight decrease in the effectiveness of Duphaston when taken in parallel with Rifampicin or Phenobarbital, which affect microsomal liver enzymes. These drugs can increase the rate of biological transformation of the hormonal drug Duphaston.

To date, there has been no information about the drug incompatibility of Duphaston with other drugs.

When prescribing a gestagen in parallel with estrogens, it is advisable to take into account the indications and contraindications for the latter.